Comparison of Intralesional Platelet Rich Plasma and 10% Dextrose Effect towards Injured Muscle Healing Comparison of Intralesional Platelet Rich Plasma and 10% Dextrose Effect towards Injured Muscle Healing

Abstract

Platelet Rich Plasma (PRP) and Dextrose 10% have prolife rant effect by promote growth factor so that it
could be use to promote healing of soft tissue. By using PRP and dextrose 10% injection intralesion in
muscle injury were hoped fasten muscle healing process and improve muscle quality. This is
experimental comparative research, was done on 27 rats that divided into 3 groups. After All of subject
got muscle injury grade II, The first group was administered with PRP, , the second group with dextrose
10%, the third group with NaCl 0,9% injection intralesion. After one week, the subjects were sacrificed,
and their gastrocnemius muscles were examined to see the level of myoblast through immuno
histochemical technique. The result show increase level of myoblast in PRP and dextrose 10% group than
control, and the level of myoblast was better in PRP group than dextrose 10% group (PRP:Dextrose
10%:NaCl 0,9% = 12,33: 8,00: 5,67). In conclusion, usage PRP and dextrose 10% injection intralesion
can increase level of myoblast in muscle injury grade 2, and usage PRP was better than dextrose 10%.