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The in-vitro anti-inflammatory activities of different extracts of Citrus lemon peal (Rutaceae) were investigated by human red blood cell membrane stabilization (HRBC) method. The alcoholic extract showed significant membrane stabilizing action on human red blood cell membrane. The HRBC Membrane stabilization activity of the alcoholic extract of Citrus lemon at concentration 400μg/ml showed 63% inhibition of denaturation in hypotonic solution while standard Aspirin 100μg/ml showed 75.34% inhibition of denaturation. Moreover, the extracts showed equipotent activity to Aspirin.