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Cadmium (Cd) is one of the most toxic environmental pollutants, causing a number of adverse health effects in humans. The main objective of this study was to evaluate the effect of cadmium on the pancreas. Mine male mice were divided into three groups: the control (Ctrl-) group, the STZ-treated diabetic control group and the Cd-treated experimental group.
STZ-treated mice which received a single dose of ip injection of 8 mg/kg of body of STZ dissolved in a freshly prepared solution of sodium citrate used as a positive control for diabetes and the control non treated mice received distilled water during the experiment. Cd-treated group had distilled water enriched with cadmium. This experiment was conducted for seven days.
Exposure of the mice to the cadmium caused a significant decrease in the animals' body weight and decrease in the blood glucose level. Our results suggest that cadmium exposure induced a sever hypoglycemia